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取扱を終了した商品ですAcid Sphingomyelinase X1695P 89-5637-44 アズワン 正規店即納

89-5637-44取扱停止Acid SphingomyelinaseX1695P 正規店即納

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  • 製品タイプ:Polyclonal Antibody
  • 製品説明:Human acid sphingomyelinase (sphingomyelin phosphodiesterase, ASM) is the lysosomal enzyme responsible for the hydrolysis of sphingomyelin to ceramide and phosphocholine. Converts sphingomyelin to ceramide. aSM also has phospholipase C activities toward 1,2-diacylglycerol-phosphocholine and 1,2-diacylglycerol-phosphoglycerol. The enzyme is a membrane-associated glycoprotein with a pH optimum of about 4.5 and a subunit molecular mass of about 72 kDa. In addition AtoS M, two other sphingomyelinases have been identified in man, a Mg2+- dependent neutral sphingomyelinase found primarily in brain and a Zn2+-dependent acid sphingomyelinase found primarily in serum. Although it is likely that the acid and neutral sphingomyelinases are coded by different genes, the molecular genetic relationship of these three biochemically distinct sphingomyelinases has not been determined. Understanding the role of these sphingomyelinases in the hydrolysis of sphingomyelin to ceramide will be an important step in the understanding of ceramide as it is further hydrolyzed to sphingosine, a neutral phospholipid which has been implicated in the regulation of protein kinase C-mediated signal transduction. Inherited deficiencies of ASM have been reported in man, deficient ASM activity results in the two major subtypes of Niemann-Pick disease (NPD).
  • アイソタイプ:N/A
  • 免疫動物:Rabbit
  • 種交差性:Human
  • クローン名:
  • カテゴリー:
  • アプリケーション:Western Blot, ELISA
  • 容量:100µg
  • 保存条件:Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
  • Accession Number:P17405
  • 免疫源:Synthetic peptide derived from human acid sphingomyelinase protein.
  • 精製方法:Ammonium Sulfate Precipitation
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